A one-step modified method to reduce the burst initial release from PLGA microspheres
نویسندگان
چکیده
منابع مشابه
Preparation of protein-loaded PLGA-PVP blend nanoparticles by nanoprecipitation method: entrapment, Initial burst and drug release kinetic studies
Objective(s):Despite of wide range applications of polymeric nanoparticles in protein delivery, there are some problems for the field of protein entrapment, initial burst and controlled release profile. Materials and Methods: In this study, we investigated the influence of some changes in PLGA nanoparticles formulation to improve the initial and controlled release profile. Selected parameters ...
متن کاملMODIFIED K-STEP METHOD FOR SOLVING FUZZY INITIAL VALUE PROBLEMS
We are concerned with the development of a K−step method for the numerical solution of fuzzy initial value problems. Convergence and stability of the method are also proved in detail. Moreover, a specific method of order 4 is found. The numerical results show that the proposed fourth order method is efficient for solving fuzzy differential equations.
متن کاملتهیه و ارزیابی برون‌تن میکروسفرهای روکش‌دار آهسته رهش ترامادول هیدروکلر‌ید
Abstract Introduction: Preparation of tramadol HCl sustained release delivery system as an analgesic drug could improve its efficacy, reduce side effects and increase patient compliance. Objective: The aim of the present study was to prepare tramadol HCl loaded microspheres and coat them by solvent evaporation (ESE) method, in order to obtain an appropriate sustained release behavior and to p...
متن کاملHeuristic modeling of macromolecule release from PLGA microspheres
Dissolution of protein macromolecules from poly(lactic-co-glycolic acid) (PLGA) particles is a complex process and still not fully understood. As such, there are difficulties in obtaining a predictive model that could be of fundamental significance in design, development, and optimization for medical applications and toxicity evaluation of PLGA-based multiparticulate dosage form. In the present...
متن کاملpreparation of protein-loaded plga-pvp blend nanoparticles by nanoprecipitation method: entrapment, initial burst and drug release kinetic studies
objective(s):despite of wide range applications of polymeric nanoparticles in protein delivery, there are some problems for the field of protein entrapment, initial burst and controlled release profile. materials and methods: in this study, we investigated the influence of some changes in plga nanoparticles formulation to improve the initial and controlled release profile. selected parameters ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Drug Delivery
سال: 2010
ISSN: 1071-7544,1521-0464
DOI: 10.3109/10717540903509001